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Best Hydrating Hand Sanitizer of 2025

Join the millions that have trusted Productpicks expert reviews and data-driven recommendations. Our curated Best Hydrating Hand Sanitizer of 2025 expertly vetted and reviewed by our professionals.

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Written by Terrick Nyron

Updated November 21, 2025

Terrick Nyron
Terrick Nyron
Terrick Nyron is an avid outdoorsman and tech enthusiast with interests from holistic agriculture to coding and everything in between. Nothing escapes my interest, and no tree is too tall!
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Best Pick
1
10/10 (881)
1
Palma de Salus 2-in-1 Home-size Moisturizing Hand Sanitizer & Hand Lotion | Avocado Oil, Jojoba Oil, Hyaluronic Acid, Centella Asiatica, Castor Oil | Neroli Scent | 70% Alcohol |11oz

palma de salus home-size moisturizing hand sanitizer

10/10 (681 reviews)
Not tested on animals
Pleasant scent
Kills 99.9% of germs
Non-greasy formula
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palma de salus home-size moisturizing hand sanitizer
This product from Palma de Salus is a convenient, 2-in-1 product that combines a moisturizing hand lotion with an effective, germ-killing sanitizer to provide deep hydration to the skin while effectively killing germs and bacteria. It is formulated with natural ingredients such as avocado oil, jojoba oil, and hyaluronic acid, and it has a refreshing neroli scent that is both invigorating and calming. Additionally, it contains 70% alcohol, which is the recommended amount by the Centers for Disease Control and Prevention (CDC) to effectively kill germs and viruses, making this an ideal product to use when you’re on the go or in situations where washing your hands is not possible. For user comfort, the non-greasy formula absorbs quickly into the skin, leaving your hands feeling soft and smooth. This item comes in a convenient 11 oz pump bottle, which provides up to 500 pumps of the product, making it an economical choice for families or businesses that require regular use of hand sanitizer. Overall, this sanitizer is a versatile and effective product that’s ideal for anyone seeking healthy, moisturized, and germ-free hands.
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Hydrating Hand Sanitizer
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FAQ
Will this product cause drying of the skin?
User reviews state this is non-drying.
palma de salus home-size moisturizing hand sanitizer
palma de salus home-size moisturizing hand sanitizer
Buying Guide
Hydrating hand sanitizers have become an essential item in our daily lives, as they allow us to maintain proper hygiene while also helping our skin stay healthy. With a multitude of options available, however, choosing the best option can feel daunting. This guide will outline key things to consider so you can easily pick the right option for you. The most important factor to consider is the active ingredient. The CDC recommends sanitizers have at least 60% alcohol content to ensure they effectively kill germs. Look for products that contain ethanol, isopropanol or n-propanol, as these are all types of germ-killing alcohols. Be sure to look at included moisturizers too, and choose a product with ingredients, such as Vitamin E, to gently hydrate your skin. Also be sure to consider the packaging size of each product you consider. Consider how you'll be using the sanitizer and where you'll be storing it. If you're on the go, a small bottle that fits in your pocket or purse may be more convenient, but if you'll be mostly using it at home or in an office, a larger bottle with a pump dispenser may be more practical. Lastly, consider the scent. Some sanitizers have no added fragrance, while others may have a fresh, or a floral scent. By keeping these things in mind, you’ll be able to easily choose the best option for your needs.
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palma de salus home-size moisturizing hand sanitizer
palma de salus home-size moisturizing hand sanitizer
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9.6
Based on 0 reviews
This product combines the power of a hand sanitizer with the nourishing properties of a moisturizing lotion, to create a 2-in-1 serum that nourishes, and softens your hands while killing 99.9% of germs. It’s FDA-registered and has a pleasant neroli scent.

Pros

  • Not tested on animals
  • Pleasant scent
  • Kills 99.9% of germs
  • Non-greasy formula
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On Amazon

Buying Guide

Hydrating hand sanitizers have become an essential item in our daily lives, as they allow us to maintain proper hygiene while also helping our skin stay healthy. With a multitude of options available, however, choosing the best option can feel daunting. This guide will outline key things to consider so you can easily pick the right option for you. The most important factor to consider is the active ingredient. The CDC recommends sanitizers have at least 60% alcohol content to ensure they effectively kill germs. Look for products that contain ethanol, isopropanol or n-propanol, as these are all types of germ-killing alcohols. Be sure to look at included moisturizers too, and choose a product with ingredients, such as Vitamin E, to gently hydrate your skin. Also be sure to consider the packaging size of each product you consider. Consider how you'll be using the sanitizer and where you'll be storing it. If you're on the go, a small bottle that fits in your pocket or purse may be more convenient, but if you'll be mostly using it at home or in an office, a larger bottle with a pump dispenser may be more practical. Lastly, consider the scent. Some sanitizers have no added fragrance, while others may have a fresh, or a floral scent. By keeping these things in mind, you’ll be able to easily choose the best option for your needs.
palma de salus home-size moisturizing hand sanitizer
palma de salus home-size moisturizing hand sanitizer

Best Hydrating Hand Sanitizer

1
Palma de Salus 2-in-1 Home-size Moisturizing Hand Sanitizer & Hand Lotion | Avocado Oil, Jojoba Oil, Hyaluronic Acid, Centella Asiatica, Castor Oil | Neroli Scent | 70% Alcohol |11oz

home-size moisturizing hand sanitizer

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Our Top Choice
10/10
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palma de salus home-size moisturizing hand sanitizer
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Productpicks is a comparison website that operates independently and is supported by advertising. The products and services featured on Productpicks come from companies that provide compensation to Productpicks. As an Amazon Associate, we earn from qualifying purchases. The compensation received may influence the placement and order of the products on the website. Productpicks utilizes various proprietary criteria to determine the display and positioning of products on the site. It's important to note that Productpicks does not encompass the entirety of available product options.

About our ranking

Our editors conduct objective reviews of products by evaluating various factors such as the features available to consumers, pricing and delivery options, product comparisons within its category, and other relevant considerations. The ratings provided are based on the expert opinions of our editors and utilize advanced technology that analyzes decisions made by similar users. This enables us to offer personalized recommendations to each individual visitor on our site.

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